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KMID : 0385219960060020014
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Korean Journal of Gerontology
1996 Volume.6 No. 2 p.14 ~ p.21
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Ameliorating Effects of Dan-shen Methanol Extract on Cognitive Deficiencies in Senescence-Accelerated Mouse
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Takashi Arima
Itsuko Baba
Hitomi Hori
Yoshihisa Kitamura
Tsuneo Namba
Masao Hattori
Kadota Shigetoshi
Yasuyuki Nomura
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Abstract
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Effect of the long-term treatment with a Dan-Shen (Salviae miltiorrhiaze radix) methanol extract(DME) on memory and learning in scenescence-accelerated mouse was investigated by means of Morris’s water maze task. DME treatment significantly decreased the escape latency and floating time in the P8 strain of scenescence-accelerated mouse (SAMP8), which strain spontaneously develops learning deficits. These results suggest that DME treatment improved spatial learning and activated emotional function. In neurochemical investigation, although no effect on choline acetyl transferase activity or [3H]QNB (quinuclidinyl benzilate) binding was observed, DME treatment caused increase in [3H]mk-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo [a,b]-cyclohepten-5,10-imine maleate) binding to the cortical membrane fraction and [3H]NNA (NG-nitro-L-arginine) binding to the cytosolic fraction of the brain stem, and decreased [3H]POBu (phorbol 12,13-dibutyrate) binding to membranes from the hippocampus, striatum, and cereballum, Thus, Our data suggests that long-term DME treatment improves spatial learning and emotional functions in SAMP8. As to the mechanism, DME treatment enhances cortical glutamatergic excitatory neurotransmission and nitric oxide synthase-related functions in the brain stem, and affects hippocampal and striatal functions mediated by protein kinase C.
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KEYWORD
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Dan-shen, SAMP8, spatial learning, NMDA((+)-5-methyl-10, 11-dihydro-5H-dibenzo [a, b]-cyclohepten-5, 10-imine maleate), PKC(phorbol 12, 13-dibutyrate), nitric oxide synthase
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